Tuesday, May 26, 2020
In light of the Cohen plea deal and the Manafort conviction, President Trump is in a precarious spot. Or is he? Better yet, is Trump closer to being impeached or are we just grasping at straws? Michael Cohen, Trumps former personal attorney, and Paul Manafort, Trumps former campaign chairman, have made headlines across the nation lately. On August 21, Cohen pleaded guilty on eight felony charges, including tax fraud and bank fraud, and was charged on violating election laws by engineering hush money payments to two women who claimed to have had affairs with Trump years back. Almost at the same moment, Manafort was convicted on eight counts and faces a maximum of 80 years in prison for five charges of tax fraud, one charge of hiding foreign bank accounts and two counts of bank fraud. This is a big deal. But what will it mean? To start, this Cohen-Manafort investigation is being run on two tracks: a political and legal track. The latter is wrapping up. The political one, however, just keeps ramping up. Perhaps the presidents impeachment depends on the Cohen plea deal and the Manafort investigation, along with special counsel, Robert Muellers Russia investigation report, which is expected to release later on this year. Right now, only Congress can decide which steps to take. But together, the Cohen plea deal, Manaforts conviction and Muellers investigation could point to the presidents political demise. Trump as a sitting president cannot be indicted, even though there is continuous debate about that. In order to bump Trump from office, the only path to take is impeachment. In the future, near or far, Congress could initiate impeachment procedures, that is if Democrats outnumber Republicans this year (which is very likely). A generic ballot from FiveThirtyEight, a website that focuses on political opinion analysis, politics and economics, shows that as of September 2, 2018, 48.8 percent of registered voters would support Democrats in a congressional election. For Republicans, 39.4 percent would support. In May of this year, The Economist revealed its 2018 election model. It gave Democrats a 65 percent chance of retaking House majority, pegging the party at 222 seats. It seems that the Democrats uphill House climb isnt as steep as everyone thought.Though these cases are closely related to Trump, there are still no charges against him yet. As this investigation continues to unfold, the truth is just waiting to hit newspaper headlines for the public in big, black, and bold letters, reading, Supreme Court finds Trump guilty of collusion. Its an administration mired in political scandal after political scandal, so there is no doubt that a negative conclusion is on the horizon. The suspicious and unscrupulous behavior in the White House should not be tolerated. As a constituent of this nation, I would like to be represented by an administration who focuses on the well-being of the people. A well-rounded president who respects all. After Trump, I hope for a competent and sophisticated successor. The future is hopeful for an impeachment. But with so many moving parts in this exhausting investigation, all we can do is wait and see.
Saturday, May 16, 2020
Richard Wright, in his novel, Native Son, favors short, simple, blunt sentences that help maintain the quick narrative pace of the novel, at least in the first two books. For example, consider the following passage: He licked his lips; he was thirsty. He looked at his watch; it was ten past eight. He would go to the kitchen and get a drink of water and then drive the car out of the garage. Wrights imagery is often brutal and elemental, as in his frequently repeated references to fire and snow and Marys bloodyÃ¢â¬ ¦show more contentÃ¢â¬ ¦But Wright goesnbsp;nbsp;nbsp;nbsp;nbsp; beyond merely presenting social data. At times Native Son seems morenbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; like a nightmare than like social science. Note that Wright was alsonbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; attracted to the horror and detective stories of Edgar Allan Poe.nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; nbsp;nbsp;One of Wrights stated goals was to make readers feel the heatnbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; of the Daltons furnace and the cold of a Chicago winter. But henbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; also makes the cold and heat symbols of the external forces alignednbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; against Bigger and of the powerful emotions raging within him. Othernbsp;nbsp;nbsp;nbsp;nbsp; nbsp;nbsp; patterns of imagery that appear throughout the novel include beastsnbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; (the rat, Bigger as a hunted animal, Bigger portrayed in thenbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; newspapers as a gorilla); suffocation (the fire being choked out bynbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; the accumulated ashes, BiggersShow MoreRelated A Marxist Reading of Native Son Essay4809 Words Ã |Ã 20 PagesA Marxist Reading of Native Son In the Communist Manifesto Karl Marx states clearly that history is a series of class struggles over the means of production. Whoever controls the means of production also controls society and is able to force their set of ideas and beliefs onto the lower class. The present dominant class ideology is, as it has been since the writing of the United States Constitution, the ideology of the upper-class, Anglo-Saxon male. Obviously, when the framers spoke of equalityRead MoreAnalysis Of James Wright s The Blues Essay2277 Words Ã |Ã 10 Pagesnotes, Burke and Ellison had the closest intellectual and social relationship when Burke was writing A Rhetoric of MotivesÃ¢â¬âand, I would add, when Ellison was writing Invisible Man. Crable points out that the Rhetoric is Ã¢â¬Å"the only one of BurkeÃ¢â¬â¢s books to cite Ellison,Ã¢â¬ in large part because EllisonÃ¢â¬â¢s 1945 essay Ã¢â¬Å"Richard WrightÃ¢â¬â¢s BluesÃ¢â¬ (which called WrightÃ¢â¬â¢s just-released memoir Black Boy Ã¢â¬Å"a nonwhite intellectualÃ¢â¬â¢s statement of his relationship to western cultureÃ¢â¬ that illuminates a Ã¢â¬Å"conflicting patternRead MoreSAT Top 30 Essay Evidence18536 Words Ã |Ã 75 Pages........ 7 Sacajawea (Mysterious Native American Guide) ....................................................................................... 9 Artists, Authors, and Musicians: Bob Dylan (Ã¢â¬Å"The Prophet of Rock and RollÃ¢â¬ ) .......................................................................................... 11 Ernest Hemingway (Troubled, brilliant author and war reporter) ............................................................ 13 Frank Lloyd Wright (AmericaÃ¢â¬â¢s legendary architect) .Read MoreASAM 5 Notes Essay6590 Words Ã |Ã 27 Pagesstories are worthy of your time What is literature A James woods: Fiction is a creaseless experiment with uncollectable data An attempt to order data with the use of story Allows us to see the wholeness of a life we cannot see in our own life Forms: Realism, modernism, post modernism Froitzan on why he writes: I want to bring pleasure with everything I writeÃ¢â¬ ¦ Ã On minority literature- Deleuze and Guattar: 3 features The deterriorializtion of a major language through a minor literatureRead MoreSummary of She Dwelt Among the Untrodden Ways11655 Words Ã |Ã 47 Pageswhich, after all, might be an idle semi-fable, improved out of slight materials. Critic Herbert Hartman believes Lucys name was taken from a neo-Arcadian commonplace, and argues she was not intended to represent any single person. In the view of one Wordsworth biographer, Mary Moorman (1906Ã¢â¬â1994), The identity of Lucy has been the problem of critics for many years. But Wordsworth is a poet before he is a biographer, and neither Lucy nor her home nor his relations with her are necessarilyRead MoreBoyer Dbq Teacher Guide10764 Words Ã |Ã 44 Pagesdiscussed in order to facilitate easy teacher reference. Students, of course, must link documents to their individual essay structures; they should not simply discuss them in the order they appear. DBQ 1: European Colonization of North America, to 1660 The supportive structure and small number of documents chosen for this question are intended to make this a good starting point for teaching students to write DBQ essays. The three criteria offered for consideration create a logical pattern of organizationRead MoreRastafarian79520 Words Ã |Ã 319 PagesEnnis Barrington Edmonds The moral rights of the authors have been asserted Database right Oxford University Press (maker) All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing of Oxford University Press, or as expressly permitted by law, or under terms agreed with the appropriate reprographics rights organization. Enquiries concerning reproduction outside the scopeRead MoreStrategic Human Resource Management View.Pdf Uploaded Successfully133347 Words Ã |Ã 534 PagesVIEW Strategic Human Resource Management Taken from: Strategic Human Resource Management, Second Edition by Charles R. Greer Copyright Ã © 2001, 1995 by Prentice-Hall, Inc. A Pearson Education Company Upper Saddle River, New Jersey 07458 Compilation Copyright Ã © 2003 by Pearson Custom Publishing All rights reserved. This copyright covers material written expressly for this volume by the editor/s as well as the compilation itself. It does not cover the individual selections herein thatRead MoreProject Managment Case Studies214937 Words Ã |Ã 860 Pages Division of Business Administration Baldwin-Wallace College Berea, Ohio John Wiley Sons, Inc. This book is printed on acid-free paper. @ Copyright O 2006 by John Wiley Sons, Inc. All rights reserved. Published by John Wiley Sons, Inc., Hoboken, New Jersey Published simultaneously in Canada No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, exceptRead MoreDeveloping Management Skills404131 Words Ã |Ã 1617 Pagesrights reserved. Manufactured in the United States of America. This publication is protected by Copyright, and permission should be obtained from the publisher prior to any prohibited reproduction, storage in a retrieval system, or transmission in any form or by any means, electronic, mechanical, photocopying, recording, or likewise. To obtain permission(s) to use material from this work, please submit a written request to Pearson Education, Inc., Permissions Department, One Lake Street, Upper Saddle
Wednesday, May 6, 2020
What is the reason for not ending the world-leading problem in the United States and in other countries? Are we capable of ending a monster that has taken the lives of children? Poverty is the monster that society worries about, especially the individuals who have to endure going days without eating and have to live in horrifying conditions. The United States has the worldÃ¢â¬â¢s second highest poverty rate among children, and the children have no way of defeating it. Many different organizations, including the government, try to tackle and improve poverty rates. Yes, we have the technology and resources to terminate this problem, but the government is not fighting hard enough. Many people try to improve poverty rates among other things butÃ¢â¬ ¦show more contentÃ¢â¬ ¦The lack of growth and development begin to occur when the body does not take in enough calcium. Calcium is very important part for the body to function because it has the function to keep bones strong and witho ut calcium the bones will become weak and break easily. Also, it will lead to stunted growth in the body and the person will not be able to grow properly. In addition, malnutrition can occur when children or the poor community does not get enough to eat and is requiring the need of nutritions and other minerals. Suffering from malnutrition will cause extensive amount of disease to manifest in the human body. Also, it will be harder for the body to fight off disease and people will become more vulnerable to catching different type of diseases. Pedro A Sanchez stated, Ã¢â¬Å"The death rate from diseases such as lower respiratory infection, malaria, and measlesÃ¢â¬ ¦Undernourished people infected with HIV/AIDS develop the full symptomsÃ¢â¬ (1). The poor population is longing for the access to healthy food in order to prevent terrible disease like this from occurring. It is very hard to treat and prevent these different variety of disease from happening without having the mone y to get the proper care and medical attention. Not only does malnutrition and not acquiring enough nutrients leads to theShow MoreRelatedThe Poverty Of The United States1727 Words Ã |Ã 7 PagesPoverty defined by the American Heritage Dictionary is Ã¢â¬Å"lack of the means of providing material needs or comfortsÃ¢â¬ (Hirokazu Yoshikawa, 2012). Poverty in the United States is an issue that is often times overlooked because the focus of poverty is on developing and struggling countries. People often think America does not experience poverty because it is such a thriving country. The problem with this is that America is indeed struggling with poverty: Ã¢â¬Å"there are currently 488 counties in America whereRead MoreThe Poverty Of The United States1548 Words Ã |Ã 7 Pagescitizens in poverty has risen. Several organizations have been set up to help those who suffer from poverty and provide their everyday needs. There are always ways where a community can help eliminate the am ount of people suffering poverty. Government has an influence on how much money flow there is in the United States such as the FED, which was created to help maintain a stable monetary and financial system and control the money supply. People themselves can also help from falling into poverty, butRead MorePoverty Of The United States1408 Words Ã |Ã 6 PagesWhen people hear the word poverty many people think of the bad connotations that come with it like, smelly homeless people that are crackheads and disease holders. Some people may even think they are uneducated or not hard working enough and rather ask for money instead of trying to get a job. Although a small portion of that may be true to some homeless people due to addictions on drugs and the toll it takes on their lives. The majority of homeless people are either veterans or immigrants, who findRead MorePoverty in the United States755 Words Ã |Ã 4 PagesPoverty in the United States is getting in inferior quality every day and nothing is being done about it. Many people who want to help the poor, but no one knows exactly how to help them. A primary reason for people not taking action is because of lack of information that is provided about issues on poverty. Poverty is defined as the state of one who lacks a usual or socially acceptable amount of money or material possessions. According to the U.S. Census Bureau data released Tuesday September 13thRead MorePoverty Of The United States Essay1369 Words Ã |Ã 6 PagesPoverty within the United States is defined as Ã¢â¬Å"having an income below a federally determined poverty threshold. Ã¢â¬ Poverty thresholds were developed by the United States government in the 60s. Over time these thresholds are adjusted to account for inflation; it is typical to adjust the poverty threshold levels annually. They represent the governmentÃ¢â¬â¢s estimate of the point below which a family has insufficient resources to meet their basic needs. Any family with le ss income than that establishedRead MoreThe Poverty Of The United States Essay1385 Words Ã |Ã 6 Pages The Character of Poverty in America Poverty has always been a key factor in United States History. Ever sense Americas birth there have been groups affected by poverty, but the forms of the poverty that affected these groups have changed as well as the nature of poverty itself in the USA. The abolition of slavery, the forced assimilation of native Americans, and mass immigration changed character of poverty within the united states change due to an evolution from agriculture to industry and a changeRead MoreThe Poverty Of The United States1531 Words Ã |Ã 7 Pagessuch dialog, topics on the increasing and rather consistent levels of poverty in some regions in America are touched on as well. Poverty is defined as a condition where oneÃ¢â¬â¢s basics needs for food, clothing, and shelter are not being met (What Is Poverty? Ã¢â¬Å"). From sea to shining sea, more than 15 percent of the American population live in poverty, a total of people over 46 million. Many who live in poverty within the United States live in areas that were once thriving from the countryÃ¢â¬â¢s economic growthRead MoreThe Poverty Of The United States1746 Words Ã |Ã 7 PagesWhat is poverty? A question most Americans will not have to think twice before answering. Poverty is, of course, simply a lack of money. The views of a specific person will defer when politics or morals are introduced, however, the idea stays the same. Those in poverty are there because they have less money than what has been decided to be livable. Poverty has changed significantly over the last two hundred years in the United States, and yet, the measurement has hardly changed since it was createdRead MorePoverty Of The United States1475 Words Ã |Ã 6 Pages Ã¢â¬Æ' Poverty in the United States is defined as a social problem. As outlined in the text, a social problem is Ã¢â¬Å"a condition that undermines the well-being of some or all members of a society and is usually a matter of public controversyÃ¢â¬ . It is easy to see that there is a large economic divide in the United States, but with only a small percentage of people in the highest income stratification and the vast majority struggling to get by, the majority of United States citizens agree that there is tooRead MorePoverty in the United States1061 Words Ã |Ã 5 PagesThe Background of Poverty in America In the United States, there are about more than forty-six million people living in impoverished conditions today. Poverty is a major conflict issue in this country amongst people who are part of the lower class because American families always had a hard time making ends meet, even before the Great Recession began. Living in poverty puts them at a disadvantage because they have to choose between necessitates like health care, child care, and food in order to
Tuesday, May 5, 2020
Question: Discuss about theMolecular Biology for Genes Diseases. Answer: Introduction The insulin-like growth factor family consists of three peptide hormones that include insulin, IGF-1 and IGH-2. They have 50% of their amino acid sequences in common (Le Roith 1997). They play a critical role in growth, differentiation and metabolism in almost every cell of the human body. Due to its diverse and far reaching roles it has been associated with several diseases and disorders and is a potential target for therapeutic intervention (Forbes 2016). IGF signaling is associated with decreased cell death and increased cell proliferation. Activation of IGF-1R leads to the activation of two pathways, PI3K/AKT and Ras/MAPK. PI3K/AKT pathway ultimately leads to decreased apoptosis, increased glucose metabolism, increased protein synthesis. On the other hand Ras/MAPK pathway leads to increased cellular proliferation by activating different transcription factors, such as ELK1. Cancer cell proliferation, migration and invasion have been related to the activation of IGF-1R in many studies previously (Sachdev and Yee 2007). Cancers in lung, breast, colon, prostate are showed to be associated with increased level of plasma IGF (Pollak, Schernhammer and Hankinson 2004). Other members of IGF pathway are also proved to be involved with malignancies. This provides a way to treat cancers via modulating IGF pathway and various ligands involved with it. Drug resistance by tumors is one of the critical conditions in new age cancer treatment. As IGF pathway is involved in cell proliferation it shows a new era of treating these kinds of situations. Many studies have shown that modulating IGF pathway has promising effect in these cases (Denduluri et al. 2015). Ovarian cancer is the fifth most frequent cause of cancer death in women. In nearly half of ovarian and breast cancer patients, RAB25 mRNAs were found to be selectivey overexpressed at stage 3 and 4 serous epitheli al ovarian cancers in comparison to other genes located in the amplified region. Decreased expression of two proteins BAK and BAX were found to be associated with an inhibition of apoptosis in such cells. Simultaneously activation of PI3K/AKT pathway provided potential mechanisms to employ the effects of RAB25 on tumor aggressiveness (Lee et al. 2015). Involvement of PI3k/AKT pathway in the RAB25 related tumor aggressiveness leads to the way to treatment by modulating this pathway. Recently various evidences show that IGF-1 promotes atherosclerotic plaque stability and consequently reduces atherosclerosis in animal models. IGF-1 induces reduction of oxidative stress, cell apoptosis, proinflammatory signaling, and endothelial dysfunction, that helps prevent the disease. Aging has been widely linked with increased vascular oxidative stress and certain vascular diseases (Barzilai et al. 2012). It has been postulated IGF-1 may play a crucial role on vascular aging processes. There are various evidences that IGF-1 exerts pleiotropic effects on the vasculature resulting in reduced vascular oxidative stress, apoptosis, and inflammatory signaling pathway (Higashi et al. 2012). By modulating IGF signaling disease related to stress or premature cell death or decreased cell death can be prevented in future. Further studies on signaling pathway of IGF show its potential role in regulation of autoimmune diseases. Though this area of treatment requires a lot more research and practical approaches, the role of IGF signaling is competent enough. Studies show that IGF-I can potentially protect animal models from developing insulin-deficient diabetes mellitus (Gao et al. 2011). On the contrary, patients with Graves disease have shown an overexpression of the IGF-1R in many cell types and antibodies against the receptor were prevalent in such patients. The frequency of IGF-IR positive B and T cells were found to be relatively high in patients with the disease. Hence, as IGF-1 and IGF-1R is found to be linked with the mentioned autoimmune disease modulation of the pathway might be a potential therapeutic target for managing the diseases and alleviating the health consequences (Smith 2010). The modulation of IGF pathway opens new ways to treat various diseases like different types of cancer, cellular stress-related diseases and immunological diseases also. It depends totally on massive research and practically showing the results on animal models to prove the modulation of IGF pathway actually showing some positive results. Comparative Genomic Hybridization: Comparative Genomic hybridization is a comparative study of two genomes by in situ hybridization technique that allows detection of differences in DNA sequences between the two genomes. Two genomes, one study and one reference genomes are differentially labeled after being denatured into single stranded DNA (Pinkel and Albertson 2005). These two genomes are then hybridized to normal metaphase spreads or to microarray. Ratio of the fluorescence intensity are then measured And plotted on a graphical manner. The graph can reveal locations of copy number changes in along the target chromosome or DNA sequences. It has been extensively used to identify genetic differences between normal cells and certain diseased cells mostly in cancer cell biology. It efficiently detects any gain or loss of genetic material in human genetic disorders by comparing the same with a reference genome, often a relevant normal cell genome. Primarily the effect of stable expression of Rab25, a hallmark of cancer has been assayed in all the parts of Figure 2. Other hallmarks that were also assayed were Bak and Bax nuclear proteins. Bak and Bax are two nuclear-encoded proteins that are capable of moving through mitochondrial membrane and induce cell death by apoptosis. Phosphorylation of AKT was also assayed during stable expression of Rab25 and in presence of RNAi. AKT or protein kinase B (PKB) is a protein kinase that plays key roles several cellular functions including apoptosis. Viral-mediated transduction is the most potent technique to produce stable cell lines with a overexpressing protein. Vectors are utilized for this purpose. Vectors are autonomously replicating DNA molecules that can be used to transfer DNA fragments to cells of interest. For transfecting mammalian cells, vectors derived from mammalian viruses are used that include Simian viruses (SV40), polyomavirus, herpesvirus and papovirus (Khan 2013). The Rab25 gene can be inserted into any one of the vector mentioned and the same gene can be transferred to an appropriate mammalian cell line by viral transfection. Mammalian cell lines that are extensively used for this purpose are HeLa, HEK293T, U2OS so on and so forth. Compared to transient transfection, stable transfected cell lines are produced to analyze impact of altered gene expression over a long time period. Generally, antibiotic resistance or fluorescent reporter cell markers are incorporated into plasmid or vector DNA to create selectio n criteria. Clonal Selection can be done by appropriate selection controls. The selected colony is used to produce monoclonal cell line development and consequently producing a stable cell line generation. The expression and stability is checked on a regular basis. The construct expression is then validated by qRT-PCR and/or Western blot techniques. Assay (e) was performed to evaluate the levels of Bak and Bax proteins in the four different ovarian cancer cell lines namely A2780 and hey and immortalized ovarian cancer cell lines T29 and T80 where there is overexpression of the protein Rab25. Bak protein levels are found to be lower in Rab25 expressing A2780, HEY and T29 cells as compared to pcDNA cells. In T80 cell lines Bak was overexpressed showing that Bak levels are regulated by other factors in certain cells. Bax levels were low in A2780 and Hey cells but not in T29 and T80 cells. In assay (f) Bak and Bax levels were measured in A2780 cells were Rab25 expression is downregulated by RNAi. The downregulation of Rab25 nullified Rab25 mediated inhibition of Bak and Bax and hence the two protein levels were found to be high in the cell lines. Bak and Bax are two nuclear proteins that can travel to mitochondrial outer membrane upon activation of relevant signaling pathway and is essential for mitochondrial permiabilisation during apoptosis (Dewson and Kluck 2009). These two proteins play a significant role in intrinsic apoptotic pathway in mammalian cells and as a result they have being extensively studied for therapeutic purposes to block apoptosis. Motility of cells where Rab25 is overexpressed or knocked down can be assayed by standard apoptotic assay methods. Cleavage of the genomic DNA into discrete fragments and consequently membrane disintegration are key features that occur during apoptosis and cell-mediated cytotoxicity. DNA cleavage being hallmark of apoptosis is often measured to assay apoptotic cell death. The DNA fragments can be assayed by ELISA quantification of histone-complexed DNA fragments. Furthermore, caspases are a class of protein that are expressed and involved in the early stages of apoptosis. Activation of the caspase proteins can be assay to determine the stage of apoptosis in a cell (Suzuki, Nakabayashi and Takahashi 2001). This can be done by in vitro enzyme assay or by detection of cleavage of an in vivo caspase substrate. Furthermore to assess the motility transwell migration assay can be performed to assess cell movement and migration. In Transwell migration assay there are two chambers; the cell s uspension placed on the upper chamber and chemoattractants are placed in the lower chamber. Cells that are motile will migrate through the membrane and get attached to the lower side of the upper chamber; non-migratory cells will remain on the upper chamber. The migratory cells can then be labeled and quantified to assess the motility of the cell lines with overexpressed and knocked out Rab25 protein. References Barzilai, N., Huffman, D.M., Muzumdar, R.H. and Bartke, A., 2012. The critical role of metabolic pathways in aging.Diabetes,61(6), pp.1315-1322. Denduluri, S.K., Idowu, O., Wang, Z., Liao, Z., Yan, Z., Mohammed, M.K., Ye, J., Wei, Q., Wang, J., Zhao, L. and Luu, H.H., 2015. Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance.Genes Diseases,2(1), pp.13-25. Dewson, G. and Kluck, R.M., 2009. Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis.Journal of cell science,122(16), pp.2801-2808. Forbes, B.E., 2016. Two years in IGF research.Growth Hormone IGF Research. Gao, J., Chesebrough, J.W., Cartlidge, S.A., Ricketts, S.A., Incognito, L., Veldman-Jones, M., Blakey, D.C., Tabrizi, M., Jallal, B., Trail, P.A. and Coats, S., 2011. Dual IGF-I/IIneutralizing antibody MEDI-573 potently inhibits IGF signaling and tumor growth.Cancer research,71(3), pp.1029-1040. Higashi, Y., Sukhanov, S., Anwar, A., Shai, S.Y. and Delafontaine, P., 2012. Aging, atherosclerosis, and IGF-1.The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, p.gls102. Khan, K.H., 2013. Gene expression in mammalian cells and its applications.Adv Pharm Bull,3(2), pp.257-63. Lee, J.S., Kang, J.H., Boo, H.J., Hwang, S.J., Hong, S., Lee, S.C., Park, Y.J., Chung, T.M., Youn, H., Lee, S.M. and Kim, B.J., 2015. STAT3-mediated IGF-2 secretion in the tumour microenvironment elicits innate resistance to anti-IGF-1R antibody.Nature communications,6. Pinkel, D. and Albertson, D.G., 2005. Comparative genomic hybridization.Annu. Rev. Genomics Hum. Genet.,6, pp.331-354. Pollak, M.N., Schernhammer, E.S. and Hankinson, S.E., 2004. Insulin-like growth factors and neoplasia.Nature Reviews Cancer,4(7), pp.505-518. Sachdev, D. and Yee, D., 2007. Disrupting insulin-like growth factor signaling as a potential cancer therapy.Molecular cancer therapeutics,6(1), pp.1-12. Smith, T.J., 2010. Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?.Pharmacological reviews,62(2), pp.199-236. Suzuki, Y., Nakabayashi, Y. and Takahashi, R., 2001. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death.Proceedings of the National Academy of Sciences,98(15), pp.8662-8667.
Thursday, April 16, 2020
Sampson and Gregory Paper In line 139 Juliet says, My only love sprung from my only hate! Two types of love are at conflict here for Juliet. Romantic love (for Romeo) and love for her family, (because she was brought up to hate the Montagues). This saddens her. There is another type of love in the play parental and familial love, the love between parents and their children. We do not learn much about the Montague parents, but we do see a great deal of the Capulet parents. At first when we see Capulet talking to Paris, he is saying Juliet is his only daughter and she means a lot to him, so he does not want her to marry as young as she is. However, this changes completely by Act 3, scene 4 when he shrewdly decides to marry off his daughter to Paris and arranges the wedding. In Act 1, scene 3, Lady Capulet has a talk with Juliet about marriage (to Paris). She does not seem to care much about Juliets opinion, but more than she does later on. This is where we see her first selfish streak, and realise that their mother-daughter relationship is not a very close one. It is not until Act 3, scene 5 we see the Capulets completely fail their daughter, when they force an arranged marriage onto her. This is a striking scene, where Lady Capulet wishes Juliet was dead after she says that she does not want to marry Paris I would the fool were married to her grave. Capulet is even more heartless in this scene. He completely loses his temper with Juliet, and threatens to throw her out and disown her is she does not marry Paris. The love of the Capulets for their daughter is so possessive and domineering, that when she doesnt do as they wish, it turns into utter cruelty and really makes you question whether they love Juliet or not. We will write a custom essay sample on Sampson and Gregory specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Sampson and Gregory specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Sampson and Gregory specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Her parents want to force her into a loveless marriage because they obviously do not consider love to be at all important in a marriage, and also because they think they know what is best for Juliet and that she is theirs to treat however they like An you be mine Ill give you to my friend; An you be not, hang, beg, starve, die in the streets, for by my soul, Ill neer acknowledge thee, (line 192-194). This also shows the contrast between young and old the old dont understand the young. Lord and Lady Capulet actually show more love for Juliet when they find her supposedly dead, but even this is selfish love as they are more worried about how they are going to live without her. This shows just how superficial their love for Juliet is. Other characters that act as surrogate parents for Romeo and Juliet and the Nurse and Friar Lawrence. The Nurse nursed Juliet as a baby, and has practically brought her up. The Friar is someone who both lovers turn to for advise. Romeo goes to the Friar when he wants to marry Juliet. The Friar and the Nurse acted as messengers between Romeo and Juliet. They showed great support and parental love towards Romeo and Juliet when they got married, but even this was partially superficial. At the end of Act 3, scene 5, just after the big argument between Capulet and Juliet, the Nurse is trying to comfort a distraught Juliet, but instead she fails her miserably. When Juliet asks the Nurse what she thinks she should do, the Nurse surprises her by saying that she might as well marry Paris because Romeo has been banished and they can no longer be together. She thinks that love (marriage) is no more than having sex and having babies, then to her Paris would make just a good husband as Romeo would. She does not understand the depth of emotion involved in true love, and Juliet is very upset by this because she thought that the Nurse understood how she felt. After this conversation, Juliet goes to the Friar for advice (Act 4, scene 1). The Friar helps her a great deal, and you think he really understands Romeo and Juliet, but he in turn fails Juliet in Act 5, scene 3. When Juliet wakes up and find Romeo dead she wants to spend more time with him, but the Friar insists that they leave when he hear people coming their way, Come Ill dispose of thee among a sisterhood of holy nuns. The Friars inadequacy in this crisis is shown by this ironic suggestion. He is fine until now to help the lovers be together, but when it comes to him nearly being caught out, he just tries to run away from the situation. This shows his selfishness, and the fact he does not understand the lovers affections and intentions to be together always. In this play of overflowing love and passion we are introduced to a character very different from all the others Paris. Paris is an altogether good man, who is genuinely in love with Juliet and is the only one genuinely upset when she dies. Here there is another situation of unrequited love for Juliet from Paris. He is quite an innocent character caught up in the Capulet familys complications and does not think there is anything wrong with the arranged marriage. He does not actually speak to Juliet until they meet in the Friars cell in Act 4, scene 1, and the marriage is arranged through Capulet. He is very thoughtful towards Juliets feelings, and in lines 6 and 7, he says he has not talked to her about love (the marriage), because she has been weeping and is very sad about Tybalts death, but thinks that by getting married she will be happy again. Another character apart from Romeo and Juliet who is also driven by great passions and love is Tybalt. Tybalt shows the greatest passion for hate. In Act 1, scene 1 he says, what, drawn and talk of peace? I hate the word, as I hate hell, and all Montagues and thee. He is a very passionate character who also shows a tremendous amount of familial love, because he is prepared to fight and in turn die for his family. Mercutio is also another one of these characters. Although he is neither Capulet nor Montague, he shows a great amount of love of friendship towards Romeo and the Montagues he dies whilst duelling against Tybalt for them. In his Queen Mab he lets his tongue run away with him because he is talking passionately about something (love) that he doesnt believe in. The mood in the scenes in which we see Romeo and Juliet together, contrast with the atmosphere of most the other scenes in the play, because of their feelings for each other. They are the two main characters who are star-crossed lovers, so obviously their scenes are going to be much more romantic and intense with passion for love than any other. Their scenes are also more calmer, relaxed and create a pleasant, positive atmosphere, whereas the rest are mainly to do with the family feud or other less positive things (such as the arranged marriage). In the balcony scene (Act 2, scene 2), you can tell that they both see their love as more important than any ancient family feud. In lines 66-69, Romeo speaks of how stony limits cannot hold love out, meaning that even high walls are no challenge for love and that nothing can stop them from sharing their love. By the end of the play Romeo and Juliet have changed quite a bit. Romeo went from being almost in a state of depression, to this fiery most positive character. However the same impulsive streak he has at the beginning is still there right till the very end when he acts on his impulse and decides to drink the poison not knowing the facts of Juliets death. Juliet was quite childish at the beginning of the play, because she does exactly what she was told by her parents. You could say that both character stayed childish right till the end, because of the way they hid everything from most people because they were too scared to come out. You could also say though that they grew up, matured a lot and became more independent because they disobeyed their parents and found a way to be together practically by themselves (even though the Nurse and the Friar knew, they did not understand Romeo and Juliet properly). I also think that by spending their first night together, Romeo and Juliet matured more as they cemented their love. They both made huge sacrifices for each other, making their love even truer, and even though they both died in the end, Romeo died after kissing Juliet, and Juliet died after kissing Romeo. Just before Romeo takes his poison, he says, heres to my love! and just before Juliet stabs herself she says Oh happy dagger! This shows they didnt mind dying as long as they were able to be together. Also in the play, the actions for the older members, affect the younger members a lot. Because of them, Mercutio, Tybalt, Paris and Romeo and Juliet all die. This is what makes Romeo and Juliet such an immense tragedy. Now I have shown the various perceptions of love in Shakespeares Romeo and Juliet, I will now pick out two contrasting scenes I have discussed and explain how I would stage them to show their differences. The two scenes I have chosen are, act 1, scene 1, with Sampson and Gregory (lines 11-27), and act 1, scene 5, where Romeo and Juliet meet for the first time (lines 94-107). Sampson and Gregory are two very crude characters, and this has to be shown by not only their performances, but also their surroundings. The actors should wear green or khaki colours, with their swords hanging from a belt on their sides. This makes them look like they are army soldiers, who are ready to fight at any moment. They would have stubble showing, and walk as if they had something heavy on their shoulders, which makes them look rough, and rude. I would have them talk very loud, almost shouting, as if they owned the place, inconsiderate to other peoples feelings and are boosting about what they are saying. The lighting should be a bold green when Sampson says, A dog of that house shall move me to stand. Green is quite a hard, sick looking colour, which will emphasise their foul minds. They should walk side-by-side, in the middle, and people should walk on the very edges (of the stage) to look as if they are trying to stay away from them. When they talk about the Montague maids and pushing them against the wall, one of them should pretend he is going to push a woman passing by into the wall, and then they both laugh about it. Romeo and Juliets first meeting is very special. In lines 94-107 they share a sonnet, so this should be a very romantic scene. Juliet should be dancing with someone else, then they all switch partners, and Romeo hurries to be hers. Until they start dancing with each other, there should be other people all around the room (on the stage), but as soon as Romeo says his first line, If I profane they should all move into the background, the music (at the party) should die slowly into a soft beat. Romeo and Juliet will dance in he middle, up-stage, and this will show the audience who they should be looking at and listening to. The lighting would hover from a calm yellow, to subtle orange, then to a soft red, then eventually to a light pink. These colours remind me of a beautiful sunset, and also romance, so I think it will work well because of the softness. They should go behind a pillar on the right side of the stage to kiss to show they are hiding it from everyone else. Romeo should wear a mask all throughout, and pull it off just before they kiss, and they should both look into each others eyes the whole time. This will show that they do not care about each others bodies. Both would be in their party outfits- Juliets should be in a long cream or white dress to show her purity, with red flowers or embroidery on it, also wearing red lipstick. Romeos outfit should be a red or maroon velvet material, with a yellow belt and silver mask. This will make him look like a prince, and the red worn by both characters, emphasises the red associated with romance. They should speak softly to each other, and when they speak it should not be as if this is their first meeting, but as if they have known each other for a lifetime. This will show the special connection they have straight away.
Friday, March 13, 2020
buy custom Mythology essay Myths address the motivations and the deepest psychological needs of the human race, which explain why myth is considerably similar all over the world. The story forming a particular myth addresses the certain themes. These themes are usually a part of the needs of human beings. Since humans needs are common throughout the world, the story in a myth reflects the experience of humans across a large segment of the planet and of time experience. Thus, they have a strong wisdom coming from the human communal experience across thousands of years. Myth speaks to humans shared dreams, common needs, motivations, desires and actions that result from them. List three each of five different types of comparative deities; include names and origins. (Example: Supreme deity: Zeus (Greek), Jupiter (Roman), God (Christian Creator deity, Culture hero, Mother goddess, Sky deity, solar deity? The most common types of myths across the humanity are: Sagas - these are mainly based on great historical events; legends - they are fictional stories and are associated with a historical place or person; and folk tales - they are just simple adventure narratives. Christianity grew out of the Mystery religions and holds many similarities yet today. List the comparative rites between Christanity and those of Attis found in the italicized paragraph on page 197. Attis was killed and resurrected after three days, which is similar to Jesus death. Secondly, Attis mother is known as the virgin goddess; comparable to Jesus mother - Virgin Mary. Attis birth is celebrated on the 25th December, similar to Jesus. Per our discussions, how was gold mined in ancient Colchis? The miners obtained gold using sheepskin. They spread a sheepskin over a board or in some way flattened it. They then placed the skin in the river and fixed it, the fleece being on the upper side, in a way that the stream would not carry it away. When the fleece soaked, it would trap gold particles. The miners withdrew the skin after some time and spread it on the ground for it to dry. When it dried, they beat it, shaking out the gold grains. What is the true message of the story of Hermaphroditus and Salmacis? The story is about the son of Aphrodite and Hermes who leaves home and goes to a spring in Caria. Salmacis is the name given to this spring. The name was for a nymph that fell in mad love for a Hermaphroditus, but did seduce him. However, while he bathed in the spring, Salmacis went forward to a frightened youth, and clung to the boy with his arms and legs around his body. He then kissed the boy, but the boy tried to fight Salmacis. Salmacis then prayed and asked the gods never to separate them from each other. The gods answered by fusing their bodies and there and then Salmacis found his body with both male and female genital and was upset. He said that any boy who bathed there would also undergo the same. Per our discussions (attachment), how are Artemis and the word Honeymoon connected? Artemis is the Greek goddess of childbirth, hunting and wildlife. She was known as Diana in the Roman mythology. She is associated with the moon, just as Apollo is associated with the sun. 8.) Who was the original deity of Delphi? Python 9.) In Blackfoot society, who owned the tipi? In this society, there are only few distinguished families that own tipis. The medicines designs originated from dreams and could be handed down to other generations. Also, it could be traded in proper ceremonies, and the rituals passed from one owner to another. 10) In her Introduction, Mary Shelley tells us in one powerful sentence why she felt her monster had to be frightening, because Victor Frankenstein tried to play God; find and quote Shelleys own words. The pale student of unhallowed arts kneeling beside the thing he had put together; to mock the stupendous mechanism of the Creator of the world by giving the "spark of life" to a "hideous corpse"(Mary). Buy custom Mythology essay
Tuesday, February 25, 2020
Management failures in entrepreneurship - Term Paper Example In order to fix a failure, people should first identify what the problem is. This paper will extensively discuss and analyze in-depth about two or three of the most common failures in entrepreneurship ventures. The failures to be analyzed and discussed here relate to financing and management execution. These form part of the major indicators of the failure of most entrepreneurial ventures. An aspiring entrepreneur can avoid these so as to succeed in an entrepreneurial career, if one is intending to set out in entrepreneurship, or if one has already started a form of business of their own (Greene 20). Wrong or Misplaced Motivation of the Entrepreneur To succeed, for someone setting out in entrepreneurship, they should be profit or success motivated or oriented. Although one cannot be told his objective, it is recommended that an entrepreneur think about it, as well as all the possible incentives, many times Ã¢â¬â and thoroughly. In fact, they should go beyond monetary values. In mo st cases, for a great majority of successful entrepreneurs, it usually comes as a surprise that most of them really like their businesses, which is the main reason behind their success. This also contributes to their monetary success, thus they receive monetary gains in doing what they love. The main argument or principle here is that if anything is set out for misplaced reasons, then it is more than likely to be terminated for the same reasons. For example, if one only considers monetary incentives while setting out on an entrepreneurial venture, and if the only intention is to generate massive money, then oneÃ¢â¬â¢s mentality will be put to a great test if zero profit is generated after approximately five years of operation. As an entrepreneur, one may want to donate cash or build a house for the needy, charity or early retirement. Whatever one may decide to do, it should be a motivation for one to keep going regardless of the tough situations he may encounter as an entrepreneur (Greene 25). Weak Management structures Numerous reports on failures in entrepreneurship view weak management structures as a major reason for lack of success by some entrepreneurs. Entrepreneurs are more than likely to fail in their business unless they make out their areas of weaknesses and look for any form of professional assistance. A successful entrepreneur comes up with a conducive work environment which encourages innovation and productivity. As an entrepreneur, one has to be good in recruiting proficient people and teaching/training them on the specifics of your business (Greene 31). Professionalism and experience are very critical in ensuring that an entrepreneurial venture succeeds. For one to succeed, he/she must recruit experienced staff/employees, who will bring in more innovative ideas to the business, hence facilitating its success to greater heights or levels in future. The modern business environment has become very competitive; hence for one to overcome the extre me market competition, he/she has to be very innovative and diverse. In the management scheme, one must be able to readily avail of marketing services. Most new enterprises just lack marketing budgets that are large. However, this is not a reason for failure to market, since if one is not doing it well, someone else more proficient in management will do it better (Greene 37). Strategic or planned marketing is very essential to the success of any business and therefore, entrepreneurs should give special attention to marketing their products, so as to make people